Role of Egg-adaptation Mutations in Low Influenza A(H3N2) Vaccine Effectiveness During the 2012–2013 Season
Author:
Affiliation:
1. British Columbia Centre for Disease Control, Vancouver
2. University of British Columbia, Vancouver
3. Institut National de Santé Publique du Québec, Quebec, Canada
4. Laval University, Quebec, Quebec, Canada
Funder
British Columbia Centre for Disease Control
Alberta Health and Wellness
Public Health Ontario
Ministère de la santé et des services sociaux
Institut national de santé publique du Québec
Public Health Agency of Canada
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Microbiology (medical)
Link
http://academic.oup.com/cid/article-pdf/67/9/1474/26038290/ciy350.pdf
Reference11 articles.
1. Low 2012-13 influenza vaccine effectiveness associated with mutation in the egg-adapted H3N2 vaccine strain not antigenic drift in circulating viruses;Skowronski;PLoS One,2014
2. Substitutions near the receptor binding site determine major antigenic change during influenza virus evolution;Koel;Science,2013
3. Poor immunogenicity, not vaccine strain egg adaptation, may explain the low H3N2 influenza vaccine effectiveness in 2012–13;Cobey;Clin Infect Dis,2018
4. Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains;Zost;Proc Natl Acad Sci U S A,2017
5. Interim estimates of 2016/17 vaccine effectiveness against influenza A(H3N2), Canada, January 2017;Skowronski;Euro Surveill,2017
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