Interim estimates of 2016/17 vaccine effectiveness against influenza A(H3N2), Canada, January 2017-Reference-Cited by-同舟云学术

Interim estimates of 2016/17 vaccine effectiveness against influenza A(H3N2), Canada, January 2017

Published:2017-02-09 Issue:6 Volume:22 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Skowronski Danuta M¹²,Chambers Catharine²,Sabaiduc Suzana²,Dickinson James A³,Winter Anne-Luise⁴,De Serres Gaston⁵⁶⁷,Drews Steven J⁸⁹,Jassem Agatha¹²,Gubbay Jonathan B¹⁰⁴,Charest Hugues⁷,Balshaw Robert¹²,Bastien Nathalie¹¹,Li Yan¹¹,Krajden Mel¹²

Affiliation:

1. University of British Columbia, Vancouver, Canada

2. British Columbia Centre for Disease Control, Vancouver, Canada

3. University of Calgary, Calgary, Canada

4. Public Health Ontario, Toronto, Canada

5. Centre Hospitalier Universitaire de Québec (University Hospital Centre of Quebec), Québec, Canada

6. Laval University, Quebec, Canada

7. Institut National de Santé Publique du Québec (National Institute of Health of Quebec), Québec, Canada

8. University of Alberta, Edmonton, Canada

9. Alberta Provincial Laboratory, Edmonton, Canada

10. University of Toronto, Toronto, Canada

11. National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada

Abstract

Using a test-negative design, the Canadian Sentinel Practitioner Surveillance Network (SPSN) assessed interim 2016/17 influenza vaccine effectiveness (VE) against dominant influenza A(H3N2) viruses considered antigenically matched to the clade 3C.2a vaccine strain. Sequence analysis revealed substantial heterogeneity in emerging 3C.2a1 variants by province and over time. Adjusted VE was 42% (95% confidence interval: 18–59%) overall, with variation by province. Interim virological and VE findings reported here warrant further investigation to inform potential vaccine reformulation.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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