mTOR masters monocyte development in bone marrow by decreasing the inhibition of STAT5 on IRF8-Reference-Cited by-全球学者库

mTOR masters monocyte development in bone marrow by decreasing the inhibition of STAT5 on IRF8

Published:2018-04-05 Issue:14 Volume:131 Page:1587-1599
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhao Yang¹²,Shen Xiaofei¹,Na Ning³,Chu Zhulang¹,Su Huiting¹,Chao Shanshan¹,Shi Lu¹,Xu Yanan¹,Zhang Lianfeng⁴⁵,Shi Bingyi⁶,Zhao Yong¹

Affiliation:

1. State Key Laboratory of Membrane Biology, Institute of Zoology and

2. University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China;

3. Department of Kidney Transplantation, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China;

4. Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Beijing, China;

5. Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing, China; and

6. Organ Transplantation Center of People’s Liberation Army, 309 Hospital of Chinese People’s Liberation Army, Beijing, China

Abstract

Key Points mTOR intrinsically controls monocyte/macrophage development in the early stage. mTOR masters monocyte development via the STAT5-IRF8-CD115 pathway.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/14/1587/1406150/blood777128.pdf

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4. Differentiation, maturation, and proliferation of macrophages in the mouse yolk sac: a light-microscopic, enzyme-cytochemical, immunohistochemical, and ultrastructural study;Takahashi;J Leukoc Biol,1989

5. Origin, development, and homeostasis of tissue-resident macrophages;Haldar;Immunol Rev,2014

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