CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation-Reference-Cited by-同舟云学术

CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation

Published:2009-03-09 Issue:3 Volume:206 Page:595-606
ISSN:1540-9538
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Auffray Cedric¹,Fogg Darin K.¹,Narni-Mancinelli Emilie²,Senechal Brigitte¹,Trouillet Celine¹³,Saederup Noah⁴,Leemput Julia⁵,Bigot Karine⁵,Campisi Laura²,Abitbol Marc⁵,Molina Thierry¹,Charo Israel⁴,Hume David A.⁶,Cumano Ana⁷,Lauvau Gregoire²,Geissmann Frederic¹³

Affiliation:

1. Laboratory of Biology of the Mononuclear Phagocyte System, Institut National de la Santé et de la Recherche Médicale (INSERM) U838, Université Paris-Descartes, 75015 Paris, France

2. INSERM U924, Université de Nice-Sophia Antipolis, 06560 Valbonne, France

3. Centre for inflammation Biology, Division of Immunity, Infection, and Inflammatory Diseases, King's College London, SE1 9RT London, England, UK

4. Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, San Francisco, CA 94158

5. Centre d'etude et de recherche therapeutique en ophtalmologie, Université Paris-Descartes, 75015 Paris, France

6. The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, EH25 9PS Roslin, Scotland, UK

7. INSERM U668, Unité de Développement des Lymphocytes, Institut Pasteur, 75015 Paris, France

Abstract

CX3CR1 expression is associated with the commitment of CSF-1R+ myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R+ CX3CR1+ macrophage/DC precursor (MDP) with other DC precursors and the role of CX3CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and monocytes, including Gr1+ inflammatory monocytes that differentiate into TipDCs during infection. CX3CR1 deficiency selectively impairs the recruitment of blood Gr1+ monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/206/3/595/1199335/jem_20081385.pdf

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