A study of lovastatin and l-arginine co-loaded PLGA nanomedicine for enhancing nitric oxide production and eNOS expression-Reference-Cited by-同舟云学术

A study of lovastatin and l-arginine co-loaded PLGA nanomedicine for enhancing nitric oxide production and eNOS expression

Published:2022 Issue:4 Volume:10 Page:607-624
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Wijaya Andy¹^ORCID,Wang Yi²,Tang Dan¹,Zhong Yuan¹,Liu Boyan¹,Yan Meng¹,Jiu Quhui¹,Wu Wei¹^ORCID,Wang Guixue¹^ORCID

Affiliation:

1. Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China

2. College of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China

Abstract

LA and LV were co-loaded in PLGA NPs. PLGA-LA/LV NPs can suppress the proliferation of VSMCs, enhance eNOS mRNA and protein expression in HUVECs, promote SR-B1 mRNA expression, and lower the total cholesterol of blood plasma in C57BL/6 mice.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Chongqing Basic Science and Advanced Technology Research Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2022/TB/D1TB01455B

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1. Atherosclerosis