Oral Nanomedicine: Challenges and Opportunities

Author:

Deng Bo123,Liu Shaomin3,Wang Ying3,Ali Barkat1,Kong Na45,Xie Tian5,Koo Seyoung4,Ouyang Jiang134,Tao Wei4ORCID

Affiliation:

1. School of Biomedical Engineering Guangzhou Medical University Guangzhou Guangdong 511436 China

2. Bioinspired Engineering and Biomechanics Center Xi′an Jiaotong University Xi′an 710049 China

3. Department of Oncology of the First Affiliated Hospital Department of Chemistry Jinan University Guangzhou 510632 China

4. Center for Nanomedicine and Department of Anesthesiology Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA

5. College of Pharmacy School of Medicine Hangzhou Normal University Hangzhou Zhejiang 311121 China

Abstract

AbstractCompared to injection administration, oral administration is free of discomfort, wound infection, and complications and has a higher compliance rate for patients with diverse diseases. However, oral administration reduces the bioavailability of medicines, especially biologics (e.g., peptides, proteins, and antibodies), due to harsh gastrointestinal biological barriers. In this context, the development and prosperity of nanotechnology have helped improve the bioactivity and oral availability of oral medicines. On this basis, first, the biological barriers to oral administration are discussed, and then oral nanomedicine based on organic and inorganic nanomaterials and their biomedical applications in diverse diseases are reviewed. Finally, the challenges and potential opportunities in the future development of oral nanomedicine, which may provide a vital reference for the eventual clinical transformation and standardized production of oral nanomedicine, are put forward.

Funder

American Lung Association

Basic and Applied Basic Research Foundation of Guangdong Province

National Natural Science Foundation of China

Publisher

Wiley

Subject

Mechanical Engineering,Mechanics of Materials,General Materials Science

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