Single-shot multi-reaction monitoring of intact marker conjugates for quantitative profiling of human major microsomal glucuronidations and its utility to screen inhibitors from medicinal herbs
Author:
Publisher
Springer Science and Business Media LLC
Subject
Biochemistry,Analytical Chemistry
Link
http://link.springer.com/content/pdf/10.1007/s00216-016-9915-z.pdf
Reference51 articles.
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3. Williams JA, Hyland R, Jones BC, Smith DA, Hurst S, Goosen TC, et al. Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004;32(11):1201–8.
4. Gradinaru J, Romand S, Geiser L, Carrupt PA, Spaggiari D, Rudaz S. Inhibition screening method of microsomal UGTs using the cocktail approach. Eur J Pharm Sci. 2015;71:35–45.
5. Seo KA, Kim HJ, Jeong ES, Abdalla N, Choi CS, Kim DH, et al. In vitro assay of six UDP-glucuronosyltransferase isoforms in human liver microsomes, using cocktails of probe substrates and liquid chromatography-tandem mass spectrometry. Drug Metab Dispos. 2014;42(11):1803–10.
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