New technologies for assessing UDP-glucuronosyltransferase (UGT) metabolism in drug discovery and development

Author:

Patten Christopher J.

Publisher

Elsevier BV

Subject

Drug Discovery,Molecular Medicine

Reference21 articles.

1. UDP-glucuronosyltransferases;Tephly,2000

2. Human UDP-glucuronosyltransferases: metabolism, expression, and disease;Tukey;Annu. Rev. Pharmacol. Toxicol.,2000

3. Integrated cytochrome P450 reaction phenotyping: attempting to bridge the gap between cDNA-expressed cytochromes P450 and native human liver microsomes;Rodriques;Biochem. Pharmacol.,1999

4. Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by addition of UGT1A1 substrates and other compounds to human liver microsomes;Williams;Drug Metab. Dispos.,2002

5. In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin;Fisher;Drug Metab. Dispos.,2000

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