Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents-Reference-Cited by-同舟云学术

Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents

Published:2015-02-26 Issue:7 Volume:64 Page:2467-2476
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Qi Qibin¹²,Downer Mary K.²,Kilpeläinen Tuomas O.³⁴,Taal H. Rob⁵⁶⁷,Barton Sheila J.⁸,Ntalla Ioanna⁹¹⁰,Standl Marie¹¹,Boraska Vesna¹²¹³,Huikari Ville¹⁴,Kiefte-de Jong Jessica C.⁶¹⁵,Körner Antje¹⁶,Lakka Timo A.¹⁷¹⁸¹⁹,Liu Gaifen²⁰,Magnusson Jessica²¹,Okuda Masayuki²²,Raitakari Olli²³²⁴,Richmond Rebecca²⁵,Scott Robert A.³,Bailey Mark E.S.²⁶,Scheuermann Kathrin¹⁶,Holloway John W.²⁷,Inskip Hazel⁸,Isasi Carmen R.¹,Mossavar-Rahmani Yasmin¹,Jaddoe Vincent W.V.⁵⁶⁷,Laitinen Jaana²⁸,Lindi Virpi¹⁷,Melén Erik²¹,Pitsiladis Yannis²⁶,Pitkänen Niina²³,Snieder Harold²⁹³⁰,Heinrich Joachim¹¹,Timpson Nicholas J.²⁵,Wang Tao¹,Yuji Hinoda³¹,Zeggini Eleftheria¹²,Dedoussis George V.⁹,Kaplan Robert C.¹,Wylie-Rosett Judith¹,Loos Ruth J.F.³³²,Hu Frank B.²³³³⁴,Qi Lu²³⁴

Affiliation:

1. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY

2. Department of Nutrition, Harvard School of Public Health, Boston, MA

3. MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital and University of Cambridge, Cambridge, U.K.

4. The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

5. The Generation R Study Group, Erasmus Medical Center, Rotterdam, the Netherlands

6. Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands

7. Department of Pediatrics, Erasmus Medical Center, Rotterdam, the Netherlands

8. MRC Lifecourse Epidemiology Unit, Faculty of Medicine, University of Southampton, Southampton, U.K.

9. Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece

10. Department of Health Sciences, University of Leicester, Leicester, U.K.

11. Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany

12. Wellcome Trust Sanger Institute, Hixton, Cambridge, U.K.

13. Department of Medical Biology, University of Split School of Medicine, Split, Croatia

14. Institute of Health Sciences, University of Oulu, Oulu, Finland

15. Global Public Health, Leiden University College, Hague, the Netherlands

16. Pediatric Research Center, Department of Women’s & Child Health, University of Leipzig, Leipzig, Germany

17. Institute of Biomedicine, Department of Physiology, University of Eastern Finland, Kuopio, Finland

18. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland

19. Kuopio Research Institute of Exercise Medicine, Kuopio, Finland

20. Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, People’s Republic of China

21. Institute of Environmental Medicine, Karolinska Institutet, and Sachs’ Children and Youth Hospital, Stockholm, Sweden

22. Graduate School of Science and Engineering, Yamaguchi University, Ube, Japan

23. The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

24. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland

25. MRC Integrative Epidemiology Unit, University of Bristol, Bristol, U.K.

26. School of Life Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, U.K.

27. Human Genetics and Medical Genomics, Faculty of Medicine, University of Southampton, Southampton, U.K.

28. Finnish Institute of Occupational Health, Oulu, Finland

29. Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

30. Georgia Prevention Center, Department of Pediatrics, Georgia Regents University, Augusta, GA

31. Hokkaido Nursing College, Chuo-ku, Sapporo, Japan

32. The Genetics of Obesity and Related Metabolic Traits Program, The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY

33. Department of Epidemiology, Harvard School of Public Health, Boston, MA

34. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

Abstract

The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for FTO variation in influencing food intake. We conducted a combined analysis of 16,094 boys and girls aged 1–18 years from 14 studies to examine the following: 1) the association between the FTO rs9939609 variant (or a proxy) and total energy and macronutrient intake; and 2) the interaction between the FTO variant and dietary intake, and the effect on BMI. We found that the BMI-increasing allele (minor allele) of the FTO variant was associated with increased total energy intake (effect per allele = 14.3 kcal/day [95% CI 5.9, 22.7 kcal/day], P = 6.5 × 10−4), but not with protein, carbohydrate, or fat intake. We also found that protein intake modified the association between the FTO variant and BMI (interactive effect per allele = 0.08 SD [0.03, 0.12 SD], P for interaction = 7.2 × 10−4): the association between FTO genotype and BMI was much stronger in individuals with high protein intake (effect per allele = 0.10 SD [0.07, 0.13 SD], P = 8.2 × 10−10) than in those with low intake (effect per allele = 0.04 SD [0.01, 0.07 SD], P = 0.02). Our results suggest that the FTO variant that confers a predisposition to higher BMI is associated with higher total energy intake, and that lower dietary protein intake attenuates the association between FTO genotype and adiposity in children and adolescents.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/64/7/2467/581210/db141629.pdf

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