Subjective Mild Depressive Symptoms are Associated With Abnormal Diurnal Cycle of Salivary Cortisol in Older Adults-Reference-Cited by-同舟云学术

Subjective Mild Depressive Symptoms are Associated With Abnormal Diurnal Cycle of Salivary Cortisol in Older Adults

Published:2010-06-17 Issue:1 Volume:24 Page:19-22
ISSN:0891-9887
Container-title:Journal of Geriatric Psychiatry and Neurology
language:en
Short-container-title:J Geriatr Psychiatry Neurol

Author:

Balardin Joana Bisol¹,Vedana Gustavo²,Luz Clarice²,Bromberg Elke³

Affiliation:

1. Institute of Geriatrics and Gerontology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil, Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil

2. Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil

3. Institute of Geriatrics and Gerontology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil, Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil, National Institute for Translational Medicine (INCT-TM), RS, Brazil,

Abstract

Background: Alterations in cortisol secretion pattern seem to be involved in the associations between aging, depression, and cognitive decline. Objective: The aim of this study was to mainly assess cortisol circadian profile in older adults with subjective depressive symptoms. Methods: Salivary cortisol samples from healthy young (n = 22) and old adults (n = 22), and from older adults who self-reported depressive symptoms in Geriatric Depression Scale (n = 22) were collected at 7 AM, 4 PM, and 10 PM and were analyzed by radioimmunoassay. Results: Older adults with depressive symptoms presented the characteristic cortisol circadian pattern, but they showed higher cortisol levels at 10 PM than healthy young and elderly controls. Conclusions: Our data suggest that mild depressive symptoms could be associated with a cortisol secretion pattern previously described as being predictive of cognitive decline.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Neurology (clinical)

Link

http://journals.sagepub.com/doi/pdf/10.1177/0891988710373599

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