Author:
Stamatatos Leonidas,Czartoski Julie,Wan Yu-Hsin,Homad Leah J.,Rubin Vanessa,Glantz Hayley,Neradilek Moni,Seydoux Emilie,Jennewein Madeleine F.,MacCamy Anna J.,Feng Junli,Mize Gregory,De Rosa Stephen C.,Finzi Andrés,Lemos Maria P.,Cohen Kristen W.,Moodie Zoe,McElrath M. Juliana,McGuire Andrew T.
Abstract
AbstractEmerging SARS-CoV-2 variants have raised concerns about resistance to neutralizing antibodies elicited by previous infection or vaccination. We examined whether sera from recovered and naïve donors collected prior to, and following immunizations with existing mRNA vaccines, could neutralize the Wuhan-Hu-1 and B.1.351 variants. Pre-vaccination sera from recovered donors neutralized Wuhan-Hu-1 and sporadically neutralized B.1.351, but a single immunization boosted neutralizing titers against all variants and SARS-CoV-1 by up to 1000-fold. Neutralization was due to antibodies targeting the receptor binding domain and was not boosted by a second immunization. Immunization of naïve donors also elicited cross-neutralizing responses, but at lower titers. Our study highlights the importance of vaccinating both uninfected and previously infected persons to elicit cross-variant neutralizing antibodies.
Publisher
Cold Spring Harbor Laboratory
Cited by
78 articles.
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