Abstract
AbstractGene set enrichment analysis (GSEA) is an important step for disease and drug discovery. Genomic, transcriptomics, proteomics and epigenetic analysis of tissue or cells generates gene lists that need to be further investigated in the known biological context. The advent of high-throughput technologies generates the vast number of gene lists that are up or down regulated together. One way of getting meaningful insights of the relationship of these genes is utilizing existing knowledge bases linking them with biological functions or phenotypes. Multiple public databases with annotated gene sets are available for GSEA, andenrichRis the most popular web application still requiring custom tools for large-scale mining.richPathRpackage is a collection of R functions that helps researchers carry out exploratory analysis and visualization of gene set enrichment usingEnrichR.AvailabilityThe package, test data and additional figures can be downloaded fromhttps://github.com/niams-bdmds/richPathR.git.Contactsunh1@nih.gov
Publisher
Cold Spring Harbor Laboratory