Abstract
AbstractSpondyloarthritis (SpA) is a group of immune-mediated diseases highly concomitant with non-musculoskeletal inflammatory disorders such as acute anterior uveitis and Crohn’s disease. The gut microbiome represents a promising avenue to elucidate their underlying pathophysiology. Using discriminatory statistical methods to disentangle disease signals from one another and potential confounders, we characterized microbial signatures shared and distinct among these diseases for the first time, and established the baseline microbiota of a mixed prospective cohort. We identified a shared immune-mediated disease signal, represented by lower abundances of Lachnospiraceae taxa, most notably Blautia and Ruminococcus gauvreauii group. Patients with SpA were specifically enriched in Collinsella and Lactobacillus co-occurring with increased inflammation, while HLA-B27+ individuals displayed enriched Faecalibacterium. Our results indicate that the shared depletion of short-chain fatty acid producing Lachnospiraceae taxa may stem from different dysbiotic states previously described as enterotypes, which reflect long-term dietary and medication patterns and capture persistent, idiosyncratic variation between individuals.
Publisher
Cold Spring Harbor Laboratory
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献