Shared and Disorder-Specific Alterations of Brain Temporal Dynamics in Obsessive-Compulsive Disorder and Schizophrenia

Author:

Luo Lekai12,Li Qian1,Wang Yaxuan1,He Ning3,Wang Yuxia1,You Wanfang1,Zhang Qian1,Long Fenghua1,Chen Lizhou1,Zhao Youjin1,Yao Li1,Sweeney John A14,Gong Qiyong1ORCID,Li Fei1ORCID

Affiliation:

1. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University , Chengdu, Sichuan , P.R. China

2. Department of Radiology, West China Second Hospital of Sichuan University , Chengdu, Sichuan , P.R. China

3. Department of Psychiatry, West China Hospital of Sichuan University , Chengdu, Sichuan , P.R. China

4. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati , Cincinnati, OH

Abstract

Abstract Background Obsessive-compulsive disorder (OCD) and schizophrenia have distinct but also overlapping symptoms. Few studies have examined the shared and disorder-specific disturbances in dynamic brain function in the 2 disorders. Study Design Resting-state functional magnetic resonance imaging data of 31 patients with OCD and 49 patients with schizophrenia, all untreated, and 45 healthy controls (HCs) were analyzed using spatial group independent component (IC) analysis. Time-varying degree centrality patterns across the whole brain were clustered into 3 reoccurring states, and state transition metrics were obtained. We further explored regional temporal variability of degree centrality for each IC across all time windows. Study Results Patients with OCD and patients with schizophrenia both showed decreased occurrence of a state having the highest centrality in the sensorimotor and auditory networks. Additionally, patients with OCD and patients with schizophrenia both exhibited reduced dynamics of degree centrality in the superior frontal gyrus than controls, while dynamic degree centrality of the cerebellum was lower in patients with schizophrenia than with OCD and HCs. Altered dynamics of degree centrality nominally correlated with symptom severity in both patient groups. Conclusions Our study provides evidence of transdiagnostic and clinically relevant functional brain abnormalities across OCD and schizophrenia in neocortex, as well as functional dynamic alterations in the cerebellum specific to schizophrenia. These findings add to the recognition of overlap in neocortical alterations in the 2 disorders, and indicate that cerebellar alterations in schizophrenia may be specifically important in schizophrenia pathophysiology via impact on cerebellar thalamocortical circuitry.

Funder

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Subject

Psychiatry and Mental health

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