Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native IKr Currents and on Cardiac Action Potential-Reference-Cited by-同舟云学术

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Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native IKr Currents and on Cardiac Action Potential

Published:2018-12-18 Issue:2 Volume:168 Page:365-380
ISSN:1096-6080
Container-title:Toxicological Sciences
language:en
Short-container-title:

Author:

Orvos Péter¹²,Kohajda Zsófia¹³,Szlovák Jozefina¹,Gazdag Péter¹,Árpádffy-Lovas Tamás¹,Tóth Dániel¹,Geramipour Amir¹,Tálosi László⁴,Jost Norbert¹³⁵,Varró András¹³⁵,Virág László¹³⁵

Affiliation:

1. Department of Pharmacology and Pharmacotherapy, Faculty of Medicine

2. Department of Ophthalmology, University of Szeged, Szeged H-6720, Hungary

3. MTA-SZTE Research Group for Cardiovascular Pharmacology, Hungarian Academy of Sciences, Szeged H-6720, Hungary

4. Department of Pharmacognosy, Faculty of Pharmacy

5. Department of Pharmacology and Pharmacotherapy, Interdisciplinary Excellence Centre, University of Szeged, Szeged H-6720, Hungary

Funder

National Research, Development and Innovation Office

Ministry of Human Capacities Hungary

HU-RO Cross-Border Cooperation Programmes

Hungarian Academy of Sciences

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Link

http://academic.oup.com/toxsci/article-pdf/168/2/365/28230137/kfy299.pdf

Reference79 articles.

1. MiRP1 forms IKr potassium channels with hERG and is associated with cardiac arrhythmia;Abbott;Cell,1999

2. hERG subunit composition determines differential drug sensitivity;Abi-Gerges;Br. J. Pharmacol,2011

3. Guide to Receptors and Channels (GRAC), 5th edition;Alexander;Br. J. Pharmacol,2011

4. Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties;Antzelevitch;Circulation,2004

5. Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs;Aslanian;Bioorg. Med. Chem. Lett,2009

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