Thyroid Function in patients with nephrotic syndrome

Author:

Alwan Salman Khawlah1,G. Ewadh Zaher1,Abdul Hamza Mohsin Mohammad1,Fadhil Alsaffar Marwa2

Affiliation:

1. Babylon Health Directorate, Iraq

2. Department of Medical Laboratory Techniques, Al-Mustaqbal University College, Iraq, 51001 Hillah, Babil, Iraq

Abstract

Nephrotic syndrome is a common pediatric kidney disease characterized by leakage of protein from the blood to the urine through damaged glomeruli. It is classically defined as nephrotic range proteinuria, hypoalbuminemia and edema. In children with nephrotic syndrome, it is probable to determine a hypothyroid state because of significant loss of thyroxine (T4) and triiodothyronine (T3) in the presence of proteinuria. This study aimed to evaluate the thyroid function in children with nephrotic syndrome and its correlation with the state of patients ( relapse or remission ). Methods: A comparative study was carried out on total of 60 patients with nephrotic syndrome (divided into two equal groups of 30 with remission and 30 with relapse ) in the age group from 1-18 years who admitted to department of nephrology in Babylon teaching hospital for Maternity and children from November 2020 to May 2021, serum albumin, serum cholesterol, thyroid stimulating hormone (TSH) and thyroxine( T4 )were done to all patients and the result compared. Result: The mean age of patients was (5.74 ± 3.77) years; most patients (N=42, 70.0%) were male. Hypothyroidism represents (N=19, 31.7%) of patients with nephrotic syndrome, while patients with normal thyroid function (euthyroid) represented (N=41, 68.3%). Significant differences existed between the means of TSH and T4 according to the patient's state (remission or relapse). There was a significant association between the state of patients and thyroid function tests. Among patients with relapse (N=19, 63.3%) presented with hypothyroidism and (N=11, 36.7%) of patients presented with normal thyroid function (euthyroid state), while among those with remission, all patients (N=30, 100%) presented with normal thyroid function (euthyroid state). In conclusion, hypothyroidism is more common in nephrotic syndrome patients during relapse, so it's important to assess thyroid function during relapse. Keywords: Thyroid, nephrotic syndrome, Nephrotic syndrome

Publisher

Clinical Biotec

Subject

Infectious Diseases,Applied Microbiology and Biotechnology,Epidemiology,Biotechnology

Reference50 articles.

1. 1. Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for Glomerulonephritis. Kidney Int. 2012;2:139–274.

2. Bionatura http://dx.doi.org/10.21931/RB/CSS/2023.08.02.46 9

3. 2. Geary DF, Schaefer F. Comprehensive Pediatric Nephrology.1st ed. Philadelphia:Mossby,2008;205_206.

4. 3. Dagan A, Cleper R, Krause I. Hypothyroidism in children with steroid-resistant nephrotic syndrome.

5. Nephrol Dial Transplant. 2012; 27: 2171-2175.

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3