1. From the Division of Cardiovascular Diseases and Internal Medicine (R.G., T.E.P., T.A.W., L.S.K., C.S.M., A.L., R.D.S.), the Molecular Medicine Program (R.G., D.J., T.E.P., T.A.W., L.S.K., C.S.M., R.G.V., R.D.S.), and the Department of Biochemistry and Molecular Biology (R.D.S.), Mayo Clinic, Rochester, Minn.