Selection of HIV Envelope Strains for Standardized Assessments of Vaccine-Elicited Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies

Author:

Mielke Dieter1ORCID,Stanfield-Oakley Sherry1,Borate Bhavesh23,Fisher Leigh H.3,Faircloth Katelyn1,Tuyishime Marina1ORCID,Greene Kelli1,Gao Hongmei1,Williamson Carolyn456,Morris Lynn5678,Ochsenbauer Christina9,Tomaras Georgia11011,Haynes Barton F.111213,Montefiori David112,Pollara Justin112,deCamp Allan C.3,Ferrari Guido11012

Affiliation:

1. Department of Surgery, Duke University, Durham, North Carolina, USA

2. Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

3. Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

4. Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa

5. National Health Laboratory Services, Johannesburg, South Africa

6. Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu Natal, Durban, South Africa

7. HIV Virology Section, Center for HIV and STIs, National Institute for Communicable Diseases, Johannesburg, South Africa

8. MRC Antibody Immunity Research Unit, University of Witwatersrand, Johannesburg, South Africa

9. Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA

10. Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA

11. Department of Immunology, Duke University, Durham, North Carolina, USA

12. Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA

13. Department of Medicine, Duke University, Durham, North Carolina, USA

Abstract

Antibody-dependent cellular cytotoxicity (ADCC) responses were found to correlate with reduced risk of infection in the RV144 trial of the only human HIV-1 vaccine to show any efficacy to date. However, reagents to understand the breadth and magnitude of these responses across preclinical and clinical vaccine trials remain underdeveloped.

Funder

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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