B.1.351 SARS-CoV-2 Variant Exhibits Higher Virulence but Less Viral Shedding than That of the Ancestral Strain in Young Nonhuman Primates-Reference-Cited by-全球学者库

B.1.351 SARS-CoV-2 Variant Exhibits Higher Virulence but Less Viral Shedding than That of the Ancestral Strain in Young Nonhuman Primates

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Bai Yu¹,He Qian¹,Yang Jinghuan¹,Lu Shuaiyao²,Mao Qunying¹,Gao Fan¹,Bian Lianlian¹,Zhang Jialu¹,An Chaoqiang¹,Liu Jianyang¹,Wu Xing¹,Yu Wenhai²,Wang Zhongfang³,Peng Xiaozhong²,Wang Junzhi¹,Liang Zhenglun¹,Xu Miao¹

Affiliation:

1. Division of Hepatitis and Enterovirus Vaccines, Institute of Biological Products, National Institutes for Food and Drug Control, NHC Key Laboratory of Research on Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, Beijing, People’s Republic of China

2. Institute of Medical Biology, Chinese Academy of Medicine Sciences & Peking Union Medical College, Kunming People’s Republic of China

3. Guangzhou Laboratory, Guangzhou, China

Abstract

One of the priorities of the current SARS-CoV-2 vaccine and drug research strategy is to determine the changes in transmission ability, virulence, and pathogenic characteristics of SARS-CoV-2 variants. In addition, nonhuman primates (NHPs) are suitable animal models for the study of the pathogenic characteristics of SARS-CoV-2 and could contribute to the understanding of pathogenicity and transmission mechanisms.

Funder

Emergency Key Program of Guangzhou Laboratory

Research on Quality Evaluation and Standardization of Innovative Vaccines of Chinese Academy of Medical Science

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02263-22

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5. The K18-Human ACE2 Transgenic Mouse Model Recapitulates Non-severe and Severe COVID-19 in Response to an Infectious Dose of the SARS-CoV-2 Virus

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