The K18-Human ACE2 Transgenic Mouse Model Recapitulates Non-severe and Severe COVID-19 in Response to an Infectious Dose of the SARS-CoV-2 Virus

Author:

Dong Wenjuan12,Mead Heather3,Tian Lei1,Park Jun-Gyu4,Garcia Juan I.4,Jaramillo Sierra3,Barr Tasha12,Kollath Daniel S.3,Coyne Vanessa K.3,Stone Nathan E.3,Jones Ashley3,Zhang Jianying5,Li Aimin6,Wang Li-Shu7,Milanes-Yearsley Martha8,Torrelles Jordi B.4,Martinez-Sobrido Luis4ORCID,Keim Paul S.3ORCID,Barker Bridget Marie3,Caligiuri Michael A.129,Yu Jianhua129ORCID

Affiliation:

1. Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA

2. Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, California, USA

3. Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA

4. Disease Intervention and Prevention, and Population Health Programs, Texas Biomedical Research Institute, San Antonio, Texas, USA

5. Department of Computational and Quantitative Medicine, City of Hope National Medical Center, Duarte, California, USA

6. Pathology Core, Shared Resources, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA

7. Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

8. Department of Pathology, The Ohio State University, Columbus, Ohio, USA

9. City of Hope Comprehensive Cancer Center, Duarte, California, USA

Abstract

The pandemic of coronavirus disease 2019 (COVID-19) has reached nearly 240 million cases, caused nearly 5 million deaths worldwide as of October 2021, and has raised an urgent need for the development of novel drugs and therapeutics to prevent the spread and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To achieve this goal, an animal model that recapitulates the features of human COVID-19 disease progress and pathogenesis is greatly needed.

Funder

California Institute for Regenerative Medicine

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Neurological Disorders and Stroke

Leukemia and Lymphoma Society

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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