Enhanced Transmissibility and Decreased Virulence of HIV-1 CRF07_BC May Explain Its Rapid Expansion in China

Author:

Cheng Zetao1,Yan Huanchang1,Li Qingmei2,Ablan Sherimay D.3,Kleinpeter Alex3,Freed Eric O.3,Wu Hao2,Dzakah Emmanuel Enoch1,Zhao Jianhui1,Han Zhigang24,Wang Haiying1,Tang Shixing1ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China

2. Guangzhou Center for Disease Control and Prevention, Guangzhou, China

3. Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA

4. Institute of Public Health, Guangzhou Medical University & Guangzhou Center for Disease Control and Prevention, Guangzhou, China

Abstract

HIV-1 CRF07_BC is one of the most common circulating recombinant forms (CRFs) in China. The question is why and how CRF07_BC expanded so rapidly remains unknown.

Funder

National Natural Foundation of Guangdong Province, China

Intramural Research Program of the Center for Cancer Research, National Cancer Institute, National Institutes of Health

Key Project of Medicine Discipline of Guangzhou

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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