Affiliation:
1. Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology , Beijing 100071 , China
2. Department of HIV/AIDS Control and Prevention, Shenzhen Center for Disease Control and Prevention , Shenzhen, Guangdong 518055 , China
Abstract
Abstract
Objectives
The ‘treat-all’ strategy was implemented in Shenzhen, China in 2016. The effect of this extensive treatment on transmitted drug resistance (TDR) of HIV is unclear.
Methods
TDR analysis was performed, based on the partial HIV-1 pol gene obtained from the newly reported HIV-1 positive cases from 2011 to 2019 in Shenzhen, China. The HIV-1 molecular transmission networks were inferred to analyse the spread of TDR. Logistic regression was used to identify the potential risk factors with TDR mutations (TDRMs) to cluster.
Results
A total of 12 320 partial pol sequences were included in this study. The prevalence of TDR was 2.95% (363/12 320), which increased from 2.57% to 3.52% after ‘treat-all’. The TDR prevalence was increased in populations with the characteristics of CRF07_BC, being single, educated to junior college level and above, MSM and male. The sensitivities of viruses to six antiretroviral drugs were decreased. The clustering rate of TDRMs remained stable, and the sequences in the three drug resistance transmission clusters (DRTCs) were mainly found during 2011–16. CRF07_BC and CRF55_01B were the factors associated with TDRMs clustering in the networks.
Conclusions
The ‘treat-all’ strategy might have contributed to a small increase in TDR, while most of the TDRMs were distributed sporadically, which implies that the ‘treat-all’ strategy is helpful for the control of TDR in high-risk populations.
Funder
NSFC
San-Ming Project of Medicine in Shenzhen
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology,Microbiology (medical)
Cited by
1 articles.
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