Author:
Livermore David M.,Mushtaq Shazad,Warner Marina,Zhang Jiancheng,Maharjan Sunil,Doumith Michel,Woodford Neil
Abstract
ABSTRACTCombinations of NXL104 with ceftazidime and aztreonam were tested against carbapenem-resistant members of theEnterobacteriaceae. Ceftazidime-NXL104 was active against strains with the OXA-48 enzyme or with combinations of impermeability and an extended-spectrum β-lactamase (ESBL) or AmpC enzyme and also against mostKlebsiellaspp. with the KPC enzyme, but metallo-β-lactamase producers were resistant. Aztreonam-NXL104 was active against all carbapenemase producers at 4 and 4 μg/ml, including those with metallo-β-lactamases.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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