Effect of the Synthetic Bile Salt Analog CamSA on the Hamster Model of Clostridium difficile Infection-Reference-Cited by-同舟云学术

Effect of the Synthetic Bile Salt Analog CamSA on the Hamster Model of Clostridium difficile Infection

Published:2018-10 Issue:10 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Howerton Amber¹,Seymour Cale O.²,Murugapiran Senthil K.²,Liao Zhenlin³,Phan Jacqueline R.⁴,Estrada Alan¹,Wagner Adam J.¹,Mefferd Chrisabelle C.²,Hedlund Brian P.²⁵,Abel-Santos Ernesto²⁴

Affiliation:

1. Department of Physical and Life Sciences, Nevada State College, Henderson, Nevada, USA

2. School of Life Sciences, University of Nevada, Las Vegas, Las Vegas, Nevada, USA

3. College of Food Science, South China Agricultural University, Guangzhou, People's Republic of China

4. Department of Chemistry, University of Nevada, Las Vegas, Las Vegas, Nevada, USA

5. Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Las Vegas, Nevada, USA

Abstract

Clostridium difficile infection (CDI) is the leading cause of antibiotic-associated diarrhea and has gained worldwide notoriety due to emerging hypervirulent strains and the high incidence of recurrence. We previously reported protection of mice from CDI using the antigerminant bile salt analog CamSA.

Funder

Nevada State College

HHS | National Institutes of Health

University of Nevada, Las Vegas

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02251-17

Reference66 articles.

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5. Centers for Disease Control and Prevention. 2013. Antibiotic resistance threats in the United States, 2013. Centers for Disease Control and Prevention, Atlanta, GA.

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