CDBN-YGXZ, a Novel Small-Molecule Drug, Shows Efficacy against Clostridioides difficile Infection and Recurrence in Mouse and Hamster Infection Models-Reference-Cited by-全球学者库

CDBN-YGXZ, a Novel Small-Molecule Drug, Shows Efficacy against Clostridioides difficile Infection and Recurrence in Mouse and Hamster Infection Models

Published:2023-05-17 Issue:5 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hu Xiaojun¹,Dong Renhan²,Huang Sheng¹,Zeng Yisheng¹,Zhan Wei²,Gao Xiaofang¹,Tian Dong¹,Peng Jian¹,Xu Jiewei¹,Wang Ting¹,Zhang Yaying¹,Wang Xiaohui³,Zhang Xiaoxia³,Liu Jin¹,Guang Bing¹²,Yang Tai¹^ORCID

Affiliation:

1. School of Pharmacy, Chengdu Medical College, Chengdu, Sichuan Province, China

2. Chengdu Biobel Biotechnology Co., Ltd., Chengdu, Sichuan Province, China

3. Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

Abstract

Clostridioides difficile infection (CDI) causes severe diarrhea and colitis, leading to significant morbidity, mortality, and high medical costs worldwide. Oral vancomycin, a first-line treatment for CDI, is associated with a high risk of recurrence, necessitating novel therapies for primary and recurrent CDI.

Funder

National Natural Science Foundation of China

Sichuan science and technology program

Chengdu Medical College

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01704-22

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