Accuracy of QuantiFERON-TB Gold Plus Test for Diagnosis of Mycobacterium tuberculosis Infection in Children

Author:

Buonsenso Danilo1,Delogu Giovanni23ORCID,Perricone Clelia1,Grossi Roberta4,Careddu Angela4,De Maio Flavio4,Palucci Ivana2,Sanguinetti Maurizio24ORCID,Valentini Piero15,Sali Michela24

Affiliation:

1. Scienze della salute della donna, del bambino e di sanità pubblica, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy

2. Istituto di Microbiologia, Università Cattolica del Sacro Cuore, Rome, Italy

3. Mater Olbia Hospital, Olbia, Italy

4. Dipartimento Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

5. Istituto di Pediatria, Università Cattolica del Sacro Cuore, Rome, Italy

Abstract

Compared to its predecessor QuantiFERON-TB Gold In Tube (QFT-IT), QuantiFERON-TB Gold Plus (QFT-Plus) contains an additional antigen tube (TB2), stimulating both CD4 + and CD8 + T cells. The ability to discriminate CD4 + and CD8 + responses is suggested to be useful in differentiating stages of Mycobacterium tuberculosis infection. While QFT-Plus has already been evaluated in adults, there are not enough data in children evaluated for suspected active tuberculosis (TB) or latent TB infection (LTBI).

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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