High Frequencies of Clindamycin and Tetracycline Resistance in Methicillin-Resistant Staphylococcus aureus Pulsed-Field Type USA300 Isolates Collected at a Boston Ambulatory Health Center

Author:

Han Linda L.1,McDougal Linda K.2,Gorwitz Rachel J.2,Mayer Kenneth H.34,Patel Jean B.2,Sennott Janet M.1,Fontana John L.1

Affiliation:

1. Massachusetts Department of Public Health, State Laboratory Institute, Jamaica Plain, Massachusetts 02130

2. Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30333

3. Fenway Community Health Center, Boston, Massachusetts 02115

4. Brown University/Miriam Hospital, Providence, Rhode Island 02906

Abstract

ABSTRACT Individual or multiple resistance to clindamycin, tetracycline, erythromycin, levofloxacin, or mupirocin was detected in a large proportion of methicillin-resistant Staphylococcus aureus pulsed-field type USA300 isolates collected at an ambulatory health center in Boston. The clindamycin, tetracycline, and mupirocin resistance genes identified in these isolates are commonly associated with plasmids.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference14 articles.

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2. Clinical and Laboratory Standards Institute. 2006. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard—seventh edition M7-A7. Clinical and Laboratory Standards Institute Wayne PA.

3. Roles of 34 Virulence Genes in the Evolution of Hospital‐ and Community‐Associated Strains of Methicillin‐ResistantStaphylococcus aureus

4. Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus

5. Gorwitz R. J. D. B. Jernigan J. H. Powers J. A. Jernigan and Participants in the CDC-Convened Experts' Meeting on Management of MRSA in the Community. 2006. Strategies for clinical management of MRSA in the community: summary of an experts' meeting convened by the Centers for Disease Control and Prevention. [Online.] http://www.cdc.gov/ncidod/dhqp/ar_mrsa_ca.html .

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