Depression in Individuals Coinfected with HIV and HCV Is Associated with Systematic Differences in the Gut Microbiome and Metabolome-Reference-Cited by-同舟云学术

Depression in Individuals Coinfected with HIV and HCV Is Associated with Systematic Differences in the Gut Microbiome and Metabolome

Published:2020-10-27 Issue:5 Volume:5 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Taylor Bryn C.¹^ORCID,Weldon Kelly C.²³,Ellis Ronald J.⁴⁵,Franklin Donald⁶,Groth Tobin⁷,Gentry Emily C.²,Tripathi Anupriya²⁷⁸,McDonald Daniel⁸^ORCID,Humphrey Gregory⁸,Bryant MacKenzie⁸,Toronczak Julia⁸,Schwartz Tara⁸,Oliveira Michelli F.⁹,Heaton Robert⁶,Grant Igor⁶,Gianella Sara¹⁰,Letendre Scott⁹¹¹,Swafford Austin³,Dorrestein Pieter C.²³⁸,Knight Rob³⁸¹²¹³^ORCID

Affiliation:

1. Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, California, USA

2. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA

3. Center for Microbiome Innovation, University of California San Diego, La Jolla, California, USA

4. Department of Neuroscience, HIV Neurobehavioral Research Center, University of California San Diego, La Jolla, California, USA

5. Department of Psychiatry, HIV Neurobehavioral Research Center, University of California San Diego, La Jolla, California, USA

6. Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California, USA

7. Division of Biological Sciences, University of California San Diego, La Jolla, California, USA

8. Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USA

9. Department of Medicine, University of California San Diego, La Jolla, California, USA

10. Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, California, USA

11. Department of Psychiatry, University of California San Diego, La Jolla, California, USA

12. Department of Computer Science and Engineering, University of California San Diego, La Jolla, California, USA

13. Department of Bioengineering, University of California San Diego, La Jolla, California, USA

Abstract

The human gut microbiome influences depression. Differences between the microbiomes of HIV-infected and uninfected individuals have been described, but it is not known whether these are due to HIV itself, or to common HIV comorbidities such as HCV coinfection. Limited research has explored the influence of the microbiome on depression within these groups. Here, we characterized the microbial community and metabolome in the stools from 373 people, noting the presence of current or lifetime depression as well as their HIV and HCV infection status. Our findings provide additional evidence that individuals with HIV have different microbiomes which are further altered by HCV coinfection. In individuals coinfected with both HIV and HCV, we identified microbes and molecules that were associated with depression. These results suggest that the interplay of HIV and HCV and the gut microbiome may contribute to the HIV-associated neuropsychiatric problems.

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00465-20

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