Characterization of the Vaginal Microbiome in Women with Infertility and Its Potential Correlation with Hormone Stimulation during In Vitro Fertilization Surgery-Reference-Cited by-全球学者库

Characterization of the Vaginal Microbiome in Women with Infertility and Its Potential Correlation with Hormone Stimulation during In Vitro Fertilization Surgery

Published:2020-08-25 Issue:4 Volume:5 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Zhao Changying¹²³,Wei Zefeng⁴,Yang Junjie⁵,Zhang Jiaming⁶,Yu Chunna⁴,Yang Aijun⁴,Zhang Min⁴,Zhang Lin⁴,Wang Ye⁷,Mu Xiaofeng⁷,Heng Xueyuan⁸,Yang Huijun⁹,Gai Zhongtao¹,Wang Xuenan⁴,Zhang Lei¹²³^ORCID

Affiliation:

1. Shandong Children’s Microbiome Center, Research Institute of Pediatrics, Qilu Children's Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China

2. Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan, China

3. Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China

4. Department of Reproductive Medicine, Affiliated Hospital of Jining Medical University, Jining, China

5. College of Life Science, Qilu Normal University, Jinan, China

6. School of Basic Medical Sciences, Shandong University, Jinan, China

7. Qingdao Human Microbiome Center, the Affiliated Central Hospital of Qingdao University, Qingdao, China

8. Microbiological Laboratory, Linyi People’s Hospital, Linyi, China

9. Maternal and Child Health Care Hospital of Shandong Province, Jinan, China

Abstract

The microbiome had been hypothesized to be involved in the physiology and pathophysiology of assisted reproduction before the first success in IVF, while the data supporting or refuting this hypothesis were less than conclusive. Thanks to sequencing data from the 16S rRNA subunit, we characterized the microbiome in the reproductive tract of infertile women, and we found that changes in the vaginal microbiome are related to female infertility. We also found that the characteristic microbiome bacteria are mainly members of several genera and that the vaginal microbiome of infertile women is not sensitive to hormonal changes during IVF. In conclusion, our report provides data that can be used for discovering the role of the vaginal microbiome in patients suffering from secondary infertility.

Funder

Shandong Provincial Key Research and Development Program

Weihai Technique Extension Project

National Natural Science Foundation of China

Taishan Scholar Project of Shandong Province

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00450-20

Reference42 articles.

1. Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century

2. Risk Factors for Secondary Infertility among Women in Karachi, Pakistan

3. Current Usage of Symbiosis and Associated Terminology

4. The Microbiome and Human Biology

5. Role played by lactobacilli in controlling the population of vaginal pathogens

Cited by 26 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A molecular view on the interference established between vaginal Lactobacilli and pathogenic Candida species: Challenges and opportunities for the development of new therapies;Microbiological Research;2024-04

2. Role of Vaginal Microbiota in Idiopathic Infertility: A Prospective Study;Microbes and Infection;2024-02

3. A Landscape View of the Female Genital Tract Microbiome in Healthy Controls and Women With Reproductive Health Conditions Associated With Ectopic Pregnancy;British Journal of Biomedical Science;2024-01-12

4. Sequencing and culture-based characterization of the vaginal and uterine microbiota in beef cattle that became pregnant or remained open following artificial insemination;Microbiology Spectrum;2023-12-12

5. Metagenomic analysis reveals a dynamic microbiome with diversified adaptive functions that respond to ovulation regulation in the mouse endometrium;BMC Genomics;2023-10-13