Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition-Reference-Cited by-同舟云学术

Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition

Published:2022-06-28 Issue:3 Volume:7 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Chen Rou-An¹,Wu Wei-Kai²,Panyod Suraphan¹,Liu Po-Yu³^ORCID,Chuang Hsiao-Li⁴,Chen Yi-Hsun³,Lyu Qiang⁵,Hsu Hsiu-Ching⁶,Lin Tzu-Lung⁷,Shen Ting-Chin David⁸,Yang Yu-Tang³,Zou Hsin-Bai⁵,Huang Huai-Syuan¹,Lin Yu-En¹,Chen Chieh-Chang⁹,Ho Chi-Tang¹⁰,Lai Hsin-Chih⁷,Wu Ming-Shiang³⁹,Hsu Cheng-Chih⁵,Sheen Lee-Yan¹¹¹¹²

Affiliation:

1. Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan

2. Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan

3. Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan

4. National Laboratory Animal Center, National Applied Research Laboratories, Taipei, Taiwan

5. Department of Chemistry, National Taiwan University, Taipei, Taiwan

6. The Metabolomics Core Laboratory, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan

7. Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan

8. Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

9. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

10. Department of Food Science, Rutgers University, New Brunswick, New Jersey, USA

11. Center for Food and Biomolecules, National Taiwan University, Taipei, Taiwan

12. National Center for Food Safety Education and Research, National Taiwan University, Taipei, Taiwan

Abstract

This study demonstrates that even with limited exposure in early life, a residual dose of tylosin might cause long-lasting metabolic disturbances by altering the gut microbiota and its metabolites. Our findings reveal that the gut microbiota is susceptible to previously ignored environmental factors.

Funder

Ministry of Science and Technology, Taiwan

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msystems.00172-22

Reference69 articles.

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