Lessons Learned and Yet-to-Be Learned on the Importance of RNA Structure in SARS-CoV-2 Replication-Reference-Cited by-全球学者库

Lessons Learned and Yet-to-Be Learned on the Importance of RNA Structure in SARS-CoV-2 Replication

Published:2022-09-21 Issue:3 Volume:86 Page:
ISSN:1092-2172
Container-title:Microbiology and Molecular Biology Reviews
language:en
Short-container-title:Microbiol Mol Biol Rev

Author:

Bassett Maclean¹²,Salemi Marco¹²^ORCID,Rife Magalis Brittany¹²^ORCID

Affiliation:

1. Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida, USA

2. Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA

Abstract

SARS-CoV-2, the etiological agent responsible for the COVID-19 pandemic, is a member of the virus family Coronaviridae , known for relatively extensive (~30-kb) RNA genomes that not only encode for numerous proteins but are also capable of forming elaborate structures. As highlighted in this review, these structures perform critical functions in various steps of the viral life cycle, ultimately impacting pathogenesis and transmissibility.

Funder

National Science Foundation

Rockefeller Foundation

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology,Infectious Diseases

Link

https://journals.asm.org/doi/pdf/10.1128/mmbr.00057-21

Reference276 articles.

1. Ritchie H Mathieu E Rodes-Guirao L Appel C Giattino C Ortiz-Ospina E Hasell J Macdonald B Beltekian D Roser M. 2020. Coronavirus pandemic (COVID-19). OurWorldInData.org. https://ourworldindata.org/coronavirus.

2. A Novel Coronavirus from Patients with Pneumonia in China, 2019

3. Centers for Disease Control and Prevention. 2021. Science brief: omicron (B.1.1.529) variant. CDC Atlanta GA. https://www.cdc.gov/coronavirus/2019-ncov/science/science-briefs/scientific-brief-omicron-variant.html.

4. Evidence of a novel RNA secondary structurein the coding region of HIV-1 pol gene

5. Structural features in TAR RNA of human and simian immunodeficiency viruses: a phylogenetic analysis

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