A Novel SXT/R391 Integrative and Conjugative Element Carries Two Copies of the bla NDM-1 Gene in Proteus mirabilis-Reference-Cited by-同舟云学术

A Novel SXT/R391 Integrative and Conjugative Element Carries Two Copies of the bla NDM-1 Gene in Proteus mirabilis

Published:2021-08-25 Issue:4 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

He Jintao¹²³,Sun Long⁴,Zhang Linghong¹²³,Leptihn Sebastian¹⁵,Yu Yunsong¹²³,Hua Xiaoting¹²³^ORCID

Affiliation:

1. Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China

2. Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, China

3. Regional Medical Center for National Institute of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China

4. Department of Clinical Laboratory, Hangzhou Women’s Hospital, Hangzhou Maternity and Child Health Care Hospital, Hangzhou, China

5. Zhejiang University, Haining, China

Abstract

The occurrence of carbapenemase-producing Proteus mirabilis , especially those strains producing NDM-1 and its variants, is a major public health concern worldwide. The integrative conjugative element (ICE) plays an important role in horizontal acquisition of resistance genes.

Funder

Zhejiang Provincial Medical and Health Science and Technology Plan

MOST | National Key Research and Development Program of China

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00588-21

Reference51 articles.

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2. First report of extensively-drug-resistant Proteus mirabilis isolate carrying plasmid-mediated blaNDM-1 in a Tunisian intensive care unit