Author:
Zhang Xiang,Huang Aijie,Liu Lixia,Qin Jiayue,Wang Chengcheng,Yang Min,Lou Yinjun,Wang Lei,Ni Xiong,Hu Xiaoxia,Tang Gusheng,Zhang Mengmeng,Cao Shanbo,Mao Liping,Qian Jiejin,Xu Weilai,Wei Juying,Xu Gaixiang,Meng Haitao,Mai Wenyuan,Yang Chunmei,Zhu Honghu,Tong Hongyan,Yang Jianmin,Yu Wenjuan,Wang Jianmin,Jin Jie
Abstract
AbstractGenetic heterogeneity poses a great challenge to the understanding and management of acute myeloid leukemia (AML). Knowledge of the IKZF1 mutation in AML specifically is extremely limited. In a previous work, we described the distribution pattern of IKZF1 mutation in AML, but its clinical impact has remained undefined due to the limited number of cases. Herein, we attempt to answer this question in one relatively large cohort covering 522 newly diagnosed AML patients. A total of 26 IKZF1 mutations were found in 20 AML patients (20/522, 3.83%). This condition has a young median age of onset of morbidity (P = 0.032). The baseline characteristics of IKZF1-mutated and wild-type patients were comparable. IKZF1 mutation showed significant co-occurrences with CEBPA (P < 0.001), SF3B1 (P < 0.001), and CSF3R (P = 0.005) mutations, and it was mutually exclusive with NPM1 mutation (P = 0.033). Although IKZF1-mutated AML was more preferably classified into the intermediate-risk group (P = 0.004), it showed one inferior complete remission rate (P = 0.032). AML with high burden of IKZF1 mutation (variant allele frequency > 0.20) showed relatively short overall survival period (P = 0.012), and it was an independent factor for the increased risk of death (hazard ratio, 6.101; 95% CI 2.278–16.335; P = 0.0003). In subgroup analysis, our results showed that IKZF1 mutation conferred poor therapeutic response and prognosis for SF3B1-mutated AML (P = 0.0017). We believe this work improves our knowledge of IKZF1 mutation.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Zhejiang Province
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Hematology
Cited by
1 articles.
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