Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

Author:

Döhner Hartmut1,Estey Elihu2,Grimwade David3,Amadori Sergio4,Appelbaum Frederick R.2,Büchner Thomas5,Dombret Hervé6,Ebert Benjamin L.7,Fenaux Pierre8,Larson Richard A.9,Levine Ross L.10,Lo-Coco Francesco4,Naoe Tomoki11,Niederwieser Dietger12,Ossenkoppele Gert J.13,Sanz Miguel14,Sierra Jorge15,Tallman Martin S.10,Tien Hwei-Fang16,Wei Andrew H.1718,Löwenberg Bob19,Bloomfield Clara D.20

Affiliation:

1. Department of Internal Medicine III, University of Ulm, Ulm, Germany;

2. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

3. Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom;

4. Department of Biomedicine and Prevention, Università di Roma “Tor Vergata,” Rome, Italy;

5. Department of Hematology/Oncology, University of Münster, Münster, Germany;

6. Institut Universitaire d’Hématologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France;

7. Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA;

8. Service d’Hématologie, Hôpital Saint-Louis, Paris, France;

9. Department of Medicine, University of Chicago, Chicago, IL;

10. Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;

11. National Hospital Organization Nagoya Medical Center, Nagoya, Japan;

12. Department of Hematology, Oncology and Hemostasis, University of Leipzig, Leipzig, Germany;

13. Department of Haematology, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands;

14. Department of Hematology, University Hospital La Fe, University of Valencia, Valencia, Spain;

15. Hematology Department, Hospital de la Santa Creu i Sant Pau, Jose Carreras Leukemia Research Institute, Barcelona, Spain;

16. Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;

17. Department of Clinical Hematology, The Alfred Hospital, Melbourne, Australia;

18. Australian Centre for Blood Diseases, Monash University, Melbourne, Australia;

19. Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands; and

20. The Ohio State University Comprehensive Cancer Center, Columbus, OH

Abstract

Abstract The first edition of the European LeukemiaNet (ELN) recommendations for diagnosis and management of acute myeloid leukemia (AML) in adults, published in 2010, has found broad acceptance by physicians and investigators caring for patients with AML. Recent advances, for example, in the discovery of the genomic landscape of the disease, in the development of assays for genetic testing and for detecting minimal residual disease (MRD), as well as in the development of novel antileukemic agents, prompted an international panel to provide updated evidence- and expert opinion-based recommendations. The recommendations include a revised version of the ELN genetic categories, a proposal for a response category based on MRD status, and criteria for progressive disease.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Cited by 4182 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3