Abstract
AbstractSuper-enhancers (SEs) consist of multiple typical enhancers enriched at high density with transcription factors, histone-modifying enzymes and cofactors. Oncogenic SEs promote tumorigenesis and malignancy by altering protein-coding gene expression and noncoding regulatory element function. Therefore, they play central roles in the treatment of cancer. Here, we review the structural characteristics, organization, identification, and functions of SEs and the underlying molecular mechanism by which SEs drive oncogenic transcription in tumor cells. We then summarize abnormal SE complexes, SE-driven coding genes, and noncoding RNAs involved in tumor development. In summary, we believe that SEs show great potential as biomarkers and therapeutic targets.
Funder
National Natural Science Foundation of China
College Excellent Youth Talent Support Program in Anhui Province
Key Projects of Natural Science Research in Colleges and Universities in Anhui Province
Research Foundation of Anhui Institute of Translational Medicine
Publisher
Springer Science and Business Media LLC