The emerging role of RNA N6-methyladenosine methylation in breast cancer

Author:

Zheng Fangchao,Du Feng,Zhao Jiuda,Wang Xue,Si Yiran,Jin Peng,Qian Haili,Xu Binghe,Yuan PengORCID

Abstract

AbstractN6-methyladenosine (m6A) modification is the most prevalent internal mRNA modification and is involved in many biological processes in eukaryotes. Accumulating evidence has demonstrated that m6A may play either a promoting or suppressing role in breast cancer, including in tumorigenesis, metastasis and angiogenesis. In this review, we summarize the latest research progress on the biological function and prognostic value of m6A modification in breast cancer, as well as potential related therapeutic strategies.

Funder

the National Key R&D Program of China

Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences Clinical and Translational Medicine Research Fund

CSCO Pilot Oncology Research Fund

Capital Health Development Research Project

Publisher

Springer Science and Business Media LLC

Subject

Biochemistry (medical),Clinical Biochemistry,Molecular Medicine

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