Author:
Tang Jinxin,Zhang Jinhui,Lu Yu,He Jieyu,Wang Hua,Liu Binfeng,Tu Chao,Li Zhihong
Abstract
AbstractN6-methyladenosine (m6A) is considered as the most common and important internal transcript modification in several diseases like type 2 diabetes, schizophrenia and especially cancer. As a main target of m6A methylation, long non-coding RNAs (lncRNAs) have been proved to regulate cellular processes at various levels, including epigenetic modification, transcriptional, post-transcriptional, translational and post-translational regulation. Recently, accumulating evidence suggests that m6A-modified lncRNAs greatly participate in the tumorigenesis of cancers. In this review, we systematically summarized the biogenesis of m6A-modified lncRNAs and the identified m6A-lncRNAs in a variety of cancers, as well as their potential diagnostic and therapeutic applications as biomarkers and therapeutic targets, hoping to shed light on the novel strategies for cancer treatment.
Funder
National Natural Foundation of China
Hunan Provincial Natural Science Foundation of China
Hunan Provincial Administration of Traditional Chinese Medicine Project
the Scientific Research Program of Hunan Provincial Health Commission
the Rehabilitation Project of Hunan Disabled Persons’ Federation
the Science and Technology Development Fund Guided by Central Government
Publisher
Springer Science and Business Media LLC
Subject
Biochemistry (medical),Clinical Biochemistry,Molecular Medicine
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