Author:
Shi Hanhan,Chai Peiwei,Jia Renbing,Fan Xianqun
Abstract
AbstractRNA modifications can be added or removed by a variety of enzymes that catalyse the necessary reactions, and these modifications play roles in essential molecular mechanisms. The prevalent modifications on mRNA include N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytosine (m5C), 5-hydroxymethylcytosine (hm5C), pseudouridine (Ψ), inosine (I), uridine (U) and ribosemethylation (2’-O-Me). Most of these modifications contribute to pre-mRNA splicing, nuclear export, transcript stability and translation initiation in eukaryotic cells. By participating in various physiological processes, RNA modifications also have regulatory roles in the pathogenesis of tumour and non-tumour diseases. We discussed the physiological roles of RNA modifications and associated these roles with disease pathogenesis. Functioning as the bridge between transcription and translation, RNA modifications are vital for the progression of numerous diseases and can even regulate the fate of cancer cells.
Funder
National Natural Science Foundation of China
SMC ChenXing Yong Scholar Program
the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant
the Innovation Fund for Translational Medicine
Ph.D. Programs Foundation of Shanghai JiaoTong University School of Medicine
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Molecular Medicine
Cited by
116 articles.
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