Author:
Chu Jie Sheng,Ge Fei Jiao,Zhang Bo,Wang Yan,Silvestris Nicola,Liu Lie Jun,Zhao Chuan Hua,Lin Li,Brunetti Anna Elisabetta,Fu Ya Li,Wang Jun,Paradiso Angelo,Xu Jian Ming
Abstract
Abstract
Background
We explore the clinical and prognostic significance of expression of vascular endothelial growth factor receptor (VEGFR)-2, platelet-derived growth factor receptor (PDGFR)-β, and c-Met in patients with hepatocellular carcinoma (HCC).
Methods
The expression of VEGFR-2, PDGFR-β, and c-Met were determined by immunohistochemical examination of the tissues of 93 HCC patients. The relationships of these markers with clinicopathological factors and prognosis were then analyzed.
Results
High expression of VEGFR-2, PDGFR-β, and c-Met was found in 86%, 19.4%, and 80.6% of patients, respectively. Expression of VEGFR-2 correlated with gender (P = 0.044), hepatitis B surface antigen positivity (P = 0.024), degree of tumor differentiation (P = 0.023), and hepatic cirrhosis (P = 0.026). Expression of PDGFR-β correlated with alpha-fetoprotein level (P = 0.029), tumor size (P = 0.033), and hepatic cirrhosis (P = 0.023). No significant correlations were identified between expression of c-Met and clinicopathological factors. Expression of PDGFR-β correlated with overall survival (P = 0.046) and expression of c-Met correlated with progression-free survival (P = 0.01).
Conclusions
We found that in patients with HCC, high expression of VEGFR-2 correlates with chronic hepatitis B virus infection and hepatic cirrhosis. High expression of PDGFR-β is a predictor of poor prognosis. High expression of C-Met may predict therapeutic effectiveness of sorafenib in HCC patients.
Publisher
Springer Science and Business Media LLC
Reference23 articles.
1. Parkin DM, Bray F, Ferlay J: Global cancer statistics, 2002. CA Cancer J Clin. 2005, 55: 74-108. 10.3322/canjclin.55.2.74.
2. Huynh H, Soo KC, Chow PK: Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244(ARRY-142886) in the treatment of hepatocellular carcinoma. Mol Cancer Ther. 2007, 6: 138-146.
3. LIovet JM, Bruix J, Gores GJ: Surgical resection versus transplantation for early hepatocellular carcinoma: clues for the best strategy. Hepatology. 2000, 31: 899-906. 10.1053/he.2000.5763.
4. Shimamura T, Saito S, Morita K: Detection of vascular endothelial growth factor and its receptor expression in human hepatocellular carcinoma biopsy specimens. J Gastroenterol Hepatol. 2000, 15: 640-646. 10.1046/j.1440-1746.2000.02201.x.
5. Yuan N, Wang P, Wang X: Expression and significance of platelet derived growth factor and its receptor in liver tissues of patients with liver fibrosis. Zhonghua Gan Zang Bing Za Zhi. 2002, 10: 58-60.
Cited by
84 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献