Rationale design and synthesis of new apoptotic thiadiazole derivatives targeting VEGFR-2: computational and <i>in vitro</i> studies-Reference-Cited by-同舟云学术

Rationale design and synthesis of new apoptotic thiadiazole derivatives targeting VEGFR-2: computational and in vitro studies

Published:2023 Issue:51 Volume:13 Page:35853-35876
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Elgammal Walid E.¹^ORCID,Elkady Hazem²^ORCID,Mahdy Hazem A.²^ORCID,Husein Dalal Z.³,Alsfouk Aisha A.⁴,Alsfouk Bshra A.⁴,Ibrahim Ibrahim M.⁵,Elkaeed Eslam B.⁶,Metwaly Ahmed M.⁷⁸^ORCID,Eissa Ibrahim H.²^ORCID

Affiliation:

1. Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt

2. Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt

3. Chemistry Department, Faculty of Science, New Valley University, El-Kharja 72511, Egypt

4. Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia

5. Biophysics Department, Faculty of Science, Cairo University, Giza 12613, Egypt

6. Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh 13713, Saudi Arabia

7. Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt

8. Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, Egypt

Abstract

This work presents the synthesis and in vitro, and in silico analyses of new thiadiazole derivatives that are designed to mimic the pharmacophoric characteristics of vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors.

Funder

Princess Nourah Bint Abdulrahman University

AlMaarefa University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA07562A

Reference77 articles.

1. International Agency for Research on Cancer , Cancer-Population Fact Sheets , https://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf , (accessed 10-10-2023, 2023)

2. Expression and prognostic significance of VEGFR-2 in breast cancer

3. Emodin, a natural anthraquinone, suppresses liver cancer in vitro and in vivo by regulating VEGFR2 and miR-34a

4. Molecular Bases of VEGFR-2-Mediated Physiological Function and Pathological Role

5. Tumor angiogenesis: causes, consequences, challenges and opportunities