CERS6-derived ceramides aggravate kidney fibrosis by inhibiting PINK1-mediated mitophagy in diabetic kidney disease-Reference-Cited by-同舟云学术

CERS6-derived ceramides aggravate kidney fibrosis by inhibiting PINK1-mediated mitophagy in diabetic kidney disease

Published:2023-08-01 Issue:2 Volume:325 Page:C538-C549
ISSN:0363-6143
Container-title:American Journal of Physiology-Cell Physiology
language:en
Short-container-title:American Journal of Physiology-Cell Physiology

Author:

Wang Xiangyu¹^ORCID,Song Minkai²,Li Xiaomin¹,Su Cailin¹,Yang Yanlin¹,Wang Kai³,Liu Cuiting⁴,Zheng Zongji¹,Jia Yijie¹,Ren Shijing¹,Dong Wenhui¹,Chen Jiaqi¹,Wang Ting⁵,Liu Lerong¹,Guan Meiping¹,Zhang Chao⁵,Xue Yaoming¹^ORCID

Affiliation:

1. Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China

2. Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China

3. Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China

4. Central Laboratory, Southern Medical University, Guangzhou, People’s Republic of China

5. Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Southern Medical University, Guangzhou, People’s Republic of China

Abstract

This article addresses the roles of ceramide synthase 6 ( CERS6) and CERS6-derived ceramides in renal tubular epithelial cells of diabetic kidney disease (DKD) associated interstitial fibrosis. Results from knockdown of CERS6 adjusted the ceramide pool in kidney cortex and markedly protected from diabetic-induced kidney fibrosis in vivo and in vitro. Mechanically, CERS6-derived ceramides might interact with PINK1 to inhibit PINK1/Parkin-mediated mitophagy and aggravate renal interstitial fibrosis in DKD.

Funder

Key-Area Research and development Program of Guangdong Province

Basic and Application Base Research Project of Guangzhou Basic Research Plan

President Foundation of Nanfang Hospital, the Southern Medical University

GDSTC | Basic and Applied Basic Research Foundation of Guangdong Province

MOST | National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Publisher

American Physiological Society

Subject

Cell Biology,Physiology

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