Mechanisms of bone blood flow regulation in humans

Author:

Draghici Adina E.12ORCID,Taylor J. Andrew12

Affiliation:

1. Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts

2. Cardiovascular Research Laboratory, Spaulding Hospital Cambridge, Cambridge, Massachusetts

Abstract

The current study is the first one to noninvasively investigate control of bone blood perfusion in vivo in humans, on a moment-by-moment basis. Our results indicate that tibial bone vasculature demonstrates active vasoconstriction in response to sympathoexcitatory stimuli in young healthy individuals. Compared with whole leg vasculature, bone vasoconstrictor response seems to be smaller, delayed, and more variable.

Funder

HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases

Paralyzed Veterans of America Research Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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