Gene expression networks in endothelial cells from failing human hearts-Reference-Cited by-同舟云学术

Gene expression networks in endothelial cells from failing human hearts

Published:2024-09-01 Issue:3 Volume:327 Page:H573-H581
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Wirth Luisa¹^ORCID,Erny Elias¹^ORCID,Krane Markus²³⁴,Lahm Harald²^ORCID,Hein Lutz¹⁵^ORCID,Gilsbach Ralf⁶⁷^ORCID,Lother Achim¹⁸^ORCID

Affiliation:

1. Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany

2. Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health, Technical University of Munich, Munich, Germany

3. Division of Cardiac Surgery, Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, United States

4. German Center for Cardiovascular Research (DZHK) – Partner Site Munich Heart Alliance, Munich, Germany

5. BIOSS Centre for Biological Signaling Studies, University of Freiburg, Freiburg, Germany

6. Institute of Experimental Cardiology, Heidelberg University Hospital, Heidelberg, Germany

7. German Center of Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Mannheim, Germany

8. Interdisciplinary Medical Intensive Care, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Abstract

Gene coexpression network analysis defined 26 gene clusters expressed in endothelial cells from failing human hearts. Transcription factors CASZ1, ZNF523, and NFE2L1 were identified as hub genes of a cluster related to angiogenesis. Knockdown of CASZ1, ZNF523, or NFE2L1 in human umbilical vein endothelial cells led to a downregulation of genes from the respective cluster, confirming their regulatory function. This provides insights into the transcriptional regulation of angiogenesis in heart failure beyond classical signaling pathways.

Funder

Deutsche Stiftung für Herzforschung

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00425.2024

Reference50 articles.

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