1. From the Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan (T.O., A.T.N., I.K.); Departments of Advanced Clinical Science and Therapeutics (H.A.) and Cardiovascular Medicine (H.A., A.T.N., I.K.), The University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan; and Japan Science and Technology Agency, Core Research for Evolutional Science and Technology (CREST), Chiyoda-ku, Tokyo, Japan (T.O., H.A., A.T.N., I.K.).