Affiliation:
1. College of Traditional Chinses Medicine, College of Traditional Chinses
Medicine, Shandong Traditional Chinese Medicine University, Jinan,
China
2. The First Clinical Medical College, Shandong Traditional Chinese
Medicine University, Jinan, China
Abstract
AbstractTranscription factor 7-like 2 (TCF7L2) polymorphism plays an essential role in
the occurrence and development of patients living with diabetes, but the current
conclusions are inconsistent on the relationship between TCF7L2 polymorphism and
the risk of diabetic nephropathy. This meta-analysis aims to explore the exact
association between TCF7L2 rs7903146 locus polymorphism and susceptibility to
diabetic nephropathy. PubMed, Embase, Web of Science, Cochrane Library, China
National Knowledge Infrastructure (CNKI), and China Wanfang databases were
searched for studies on the relationship between single nucleotide polymorphism
at TCF7L2 rs7903146 locus and susceptibility to diabetic nephropathy until
January 10, 2022. The data were analyzed by Stata 15.0 software. A total of 7
articles were included, covering 1443 patients with diabetic nephropathy and
2129 diabetic non-nephropathy patients. The results showed that allele C at
TCF7L2 rs7903146 locus, compared to allele T, the pooled odds ratio
(OR)=0.69 (95% CI: 0.56–0.85, p≤0.05). In the
dominant gene inheritance model, recessive gene inheritance model, homozygous
genetic model, and heterozygous genetic model, the pooled OR was 0.47
(95% CI: 0.36–0.61), 0.63 (95% CI: 0.54–0.73),
0.39 (95% CI: 0.29–0.51), and 0.59 (95% CI:
0.45–0.78), respectively, and the differences were statistically
significant. In conclusion, TCF7L2 rs7903146 polymorphism is associated with
susceptibility to diabetic nephropathy. Allele T and genotype TT can increase
the risk of diabetic nephropathy.
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
2 articles.
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