Transcription Factor 7-like 2 Gene Polymorphism and Type 2 Diabetes Mellitus: A Meta-analysis

Abstract

Abstract The meta-analysis aimed to investigate transcription factor 7-like 2 (TCF7 L2) (rs12255372 and rs7903146) gene polymorphisms and its association with type 2 diabetes mellitus (T2DM) in a Caucasian and Asian population. The studies included in this article were obtained using online databases. We searched databases such as Scopus, Web of Science, Embase, and PubMed for case–control articles related to TCF7 L2 polymorphisms and T2DM. To determine TCF7 L2 polymorphisms are significantly associated with T2DM, Metagenyo was used to calculate the odds ratio and 95% confidence interval. A total of 15 articles were included in this meta-analysis. TCF7 L2 rs12255372 and rs7903146 gene polymorphisms were strongly related to susceptibility to T2DM in the general population, as shown by the results of a meta-analysis. Subgroup analysis showed that both Asians and Caucasians showed a statistically significant result. This meta-analysis findings supported that TCF7 L2 rs12255372 and rs7903146 gene polymorphisms to determine susceptibility with type 2 diabetes. According to the findings of this study, people with TCF7 L2 gene polymorphisms rs12255372 for allelic, recessive, dominant, and over-dominant models have been connected to T2DM; however, rs7903146 for allelic, recessive, dominant, and over-dominant models have not been associated to the disease.