Second primary malignancies in ruxolitinib-treated myelofibrosis: real-world evidence from 219 consecutive patients

Author:

Maffioli Margherita1ORCID,Giorgino Toni23ORCID,Mora Barbara1,Iurlo Alessandra4ORCID,Elli Elena5ORCID,Finazzi Maria Chiara6,Caramella Marianna7,Rumi Elisa8ORCID,Carraro Maria Cristina9,Polverelli Nicola10ORCID,D’Adda Mariella11,Malato Simona12,Rossi Marianna13,Molteni Alfredo14ORCID,Vismara Alessandro15,Sissa Cinzia16,Spina Francesco17,Anghilieri Michela18,Cattaneo Daniele4,Renso Rossella5,Bellini Marta6,Pioltelli Maria Luisa7,Cavalloni Chiara8,Barraco Daniela1,Accetta Raffaella19,Bertù Lorenza20,Della Porta Matteo Giovanni13,Passamonti Francesco20

Affiliation:

1. Hematology Unit, Ospedale di Circolo, ASST Sette Laghi, Varese, Italy;

2. Biophysics Institute (IBF-CNR), National Research Council of Italy, Milan, Italy;

3. Department of Biosciences, University of Milan, Milan, Italy;

4. Hematology Division, Foundation Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy;

5. Hematology Division and Bone Marrow Unit, Ospedale San Gerardo, Monza, Italy;

6. Department of Hematology, ASST Papa Giovanni XXIII, Bergamo, Italy;

7. Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy;

8. Department of Molecular Medicine, University of Pavia, Pavia, Italy;

9. Hematology and Transfusional Medicine Unit, ASST Fatebenefratelli Sacco, Milan, Italy;

10. Unit of Blood Diseases and Stem Cell Transplantation, ASST Spedali Civili di Brescia, Brescia, Italy;

11. Department of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy;

12. Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy;

13. Department of Hematology, Cancer Center, IRCCS Humanitas Research Hospital/Humanitas University, Rozzano, Italy;

14. Hematology Unit, ASST Cremona, Cremona, Italy;

15. Onco-Hematology Unit, ASST-Rhodense, Rho, Italy;

16. Department of Hematology and Transfusion Medicine, ASST Mantova, Mantova, Italy;

17. Hematology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;

18. Oncology Department, ASST Lecco, Lecco, Italy;

19. Cytogenetics and Genetics Laboratory, Ospedale di Circolo, ASST Sette Laghi, Varese, Italy; and

20. Department of Medicine and Surgery, University of Insubria, ASST Sette Laghi–Ospedale di Circolo, Varese, Italy

Abstract

Key PointsWe present real-world data on all ruxolitinib-treated myelofibrosis patients in a 10-million-resident region, with a follow-up of 2 years. We found no evidence of an increased risk of developing lymphomas.

Publisher

American Society of Hematology

Subject

Hematology

Reference18 articles.

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