Outcomes and characteristics of nonmelanoma skin cancers in patients with myeloproliferative neoplasms on ruxolitinib-Reference-Cited by-同舟云学术

Outcomes and characteristics of nonmelanoma skin cancers in patients with myeloproliferative neoplasms on ruxolitinib

Published:2024-01-11 Issue:2 Volume:143 Page:178-182
ISSN:0006-4971
Container-title:Blood
language:en
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Author:

Rampotas Alex¹,Carter-Brzezinski Luke²³,Somervaille Tim C. P.²³,Forryan James¹,Panitsas Fotios⁴^ORCID,Harrison Claire⁵,Witherall Ruth⁶,Innes Andrew J.⁷^ORCID,Wallis Louise⁸,Butt Naumann M.⁹,Psaila Bethan¹⁰^ORCID,Mead Adam J.¹⁰^ORCID,Carter Matthew¹¹,Godfrey Anna L.¹¹,Laing Heather¹²,Garg Mamta¹²^ORCID,Francis Sebastian¹³,Ewing Joanne¹⁴,Teh Chun Huat¹⁵,Cowen Hannah Bibi⁵,Dyer Peter¹⁶,McConville Conall¹⁷,Wadelin Frances¹⁸,Sahra Ali¹⁹,McGregor Andrew²⁰,Kulakov Elizabeth²¹,McLornan Donal P.¹,Lambert Jonathan¹

Affiliation:

1. 1Haematology Department, University College London Hospital NHS Foundation Trust, London, United Kingdom

2. 2Cancer Research UK Manchester Institute, Manchester, United Kingdom

3. 3Haematology Department, The Christie NHS Foundation Trust, Manchester, United Kingdom

4. 4Haematology Department, Laikon University Hospital of Athens, Athens, Greece

5. 5Haematology Department, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom

6. 6Haematology Department, Royal Cornwall Hospitals NHS Foundation Trust, Treliske, United Kingdom

7. 7Haematology Department, Imperial College Healthcare NHS Trust, London, United Kingdom

8. 8Haematology Department, University Hospitals Dorset NHS Foundation Trust, Bournemouth, United Kingdom

9. 9Haematology Department, The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, United Kingdom

10. 10Department of Haematology and NIHR Biomedical Research Centre, OUH NHS Foundation Trust, Oxford, United Kingdom

11. 11Haematology Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom

12. 12University Hospitals of Leicester NHS Trust, Leicester, United Kingdom

13. 13Haematology Department, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom

14. 14Haematology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom

15. 15Haematology Department, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

16. 16Haematology Department, University Hospitals of North Midlands, Stoke-on-Trent, United Kingdom

17. 17Department of Haematology, Altnagelvin Area Hospital, North West Cancer Centre, Derry, United Kingdom

18. 18Haematology Department, Nottingham University Hospital NHS Foundation Trust, Nottingham, United Kingdom

19. 19Haematology Department, King’s College London Hospital NHS Foundation Trust, London, United Kingdom

20. 20Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom

21. 21Dermatology Department, University College London Hospital NHS Foundation Trust, London, United Kingdom

Abstract

Abstract Nonmelanoma skin cancers (NMSCs) in ruxolitinib-treated patients with myeloproliferative neoplasms behave aggressively, with adverse features and high recurrence. In our cohort, mortality from metastatic NMSC exceeded that from myelofibrosis. Vigilant skin assessment, counseling on NMSC risks, and prospective ruxolitinib-NMSC studies are crucial.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

https://ashpublications.org/blood/article-pdf/143/2/178/2180218/blood_bld-2023-022345-main.pdf

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