Genetic alterations of the cohesin complex genes in myeloid malignancies-Reference-Cited by-同舟云学术

Genetic alterations of the cohesin complex genes in myeloid malignancies

Published:2014-09-11 Issue:11 Volume:124 Page:1790-1798
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Thota Swapna¹,Viny Aaron D.²^ORCID,Makishima Hideki¹,Spitzer Barbara²,Radivoyevitch Tomas³^ORCID,Przychodzen Bartlomiej¹,Sekeres Mikkael A.¹,Levine Ross L.²,Maciejewski Jaroslaw P.¹

Affiliation:

1. Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;

2. Human Oncology and Pathogenesis Program and Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY; and

3. Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH

Abstract

Key Points Recurrent hypomorphic cohesin defects and cohesin low expression were identified in a significant proportion of patients with MDS and AML. Cohesin mutations likely represent secondary events in clonal hierarchy and contribute to clonal transformation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/11/1790/1468488/1790.pdf

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4. Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibition.;Bailey;Mol Cancer Ther,2014

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