Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications

Author:

Thol Felicitas1,Bollin Robin1,Gehlhaar Marten1,Walter Carolin2,Dugas Martin2,Suchanek Karl Josef1,Kirchner Aylin1,Huang Liu13,Chaturvedi Anuhar1,Wichmann Martin1,Wiehlmann Lutz4,Shahswar Rabia1,Damm Frederik5,Göhring Gudrun6,Schlegelberger Brigitte6,Schlenk Richard7,Döhner Konstanze7,Döhner Hartmut7,Krauter Jürgen18,Ganser Arnold1,Heuser Michael1

Affiliation:

1. Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany;

2. Institute of Medical Informatics, Münster University, Münster, Germany;

3. Department of Oncology, Tongji Hospital, Tongji Medical College, University of Science and Technology, Huazhong, China;

4. Clinical Research Group, Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany;

5. Department of Hematology, Oncology, and Tumor Immunology, Charité, Berlin, Germany;

6. Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany;

7. Department of Internal Medicine III, University of Ulm, Ulm, Germany; and

8. Klinikum Braunschweig, Braunschweig, Germany

Abstract

Key Points Mutations in genes of the cohesin complex are recurrent mutations in AML with a strong association with NPM1 mutations. Cohesin gene mutations have no clear prognostic impact in AML patients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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